Scientific publications
Explore the publications from TNO‑ESI, showcasing our research findings and expertise. This includes peer-reviewed articles, conference papers, and research reports, as well as more accessible publications that share insights from our collaborations with industry partners. You can easily search the publications by keyword to find what is most relevant to you.
- Year
- 2025
- Authors
- Sanden, L.J. van der; Veen, L.M.F. van; Blankenstein, Y.; Hendriks, D.; Hegge, J.J.A.; Oortwijn, W.A.M.; Peruffo, A.
Stakeholder analysis in applied research projects
In applied research projects, we want to create impact by developing innovative solutions, and land them in the organization. Successfully landing innovations typically requires a direct collaboration with stakeholders in the organization. They need to adopt the results in the system they develop or embed them in their systems development process and way-ofworking.
- Year
- 2025
- Authors
- Oortwijn, W.H.M.; Hooman,J.; Bera, D.; Corvino, R.; Dams, D.R.; Hegge, J.; Hendriks, D.; Laar, P.J.L.J. van de; Minten, J.; Yang, N.
Vision and Outlook for System Evolution and Diversity
High-tech cyber-physical systems (CPS) are becoming increasingly diverse: they may have many variations and configurations, might be part of product families, and may be highly customizable. Additionally, CPSs tend to continuously evolve—have variation in time—for example due to technology updates, changing demands, or changing requirements.
- Year
- 2025
- Authors
- Triantafyllidis, K.; Niknam, S.; Blankenstein, Y.; Hegge, J.
Platform Performance Suite (PPS): A framework for performance analysis & diagnosis of complex cyber-physical systems
The performance of cyber-physical systems (CPS) is a determining factor for their success and often needs to be guaranteed. When performance issues occur, their analysis and the identification of the root-cause should be fast. Typically the analysis requires the relation of system observations (i.e., tracing) to design and implementation artifacts.
- Year
- 2025
- Authors
- Nägele, T.C.; Barbini, L.; Braak, G.J.W. van den; Piedrafita Postigo, A.; Lipplaa, M.M.
SD2Act 2024: Guided diagnosis of functional failures in cyber-physical systems
- Year
- 2025
- Authors
- Muller, G.
What roles of politicians, managers, and systems engineering will be effective in sociotechnical systems?
The functionality that we use as organizations and citizens increasingly arises from a complex interplay of man-built systems, individuals and organizations, and the environment. It is a challenge to get the desired functionality and features consistently, reliably and affordably, without unwanted side effects.
- Year
- 2024
- Authors
- Saadatmand, F.S.; Stefanov, T.; González Alonso, I.; Pimentel, A.D.; Akesson, B.; Herget, M.; Bor, M.
Automated Derivation of Application Workload Models for Design Space Exploration of Industrial Distributed Cyber-Physical Systems
Manufacturing companies of complex distributed cyber-physical systems (dCPS) are encountering challenges with respect to designing their next-generation machines. They need efficient Design Space Exploration (DSE) techniques to evaluate possible design decisions and their consequences on nonfunctional aspects of the systems.
- Year
- 2024
- Authors
- Kurtev, I.; Hooman, J.; Schuts, M.; Munnik, D. van der
Model based component development and analysis with ComMA
- Published in
- Science of Computer Programming, 233, pp. 1-14.
The lack of explicit and precise specifications of software interfaces between components often leads to integration issues during development and maintenance. To address this, we have developed a framework named ComMA (Component Modeling and Analysis) that supports model based engineering of high-tech systems by precisely defining components and their interfaces.
- Year
- 2024
- Authors
- Mooij, A.J.; Laar, P. van de
AST Matching based on Concrete Syntax Patterns: Exploration of the Specification Challenges
Software analysis often relies on pattern matching in terms of Abstract Syntax Trees (ASTs), but AST patterns are known to be tedious to specify. Concrete syntax patterns with placeholders have been proposed as a user-friendly alternative. Several designs for this proposal have been implemented, but these typically focus on specific parsing technologies.
- Year
- 2024
- Authors
- Vanrompay, H.; Javaheri, N.; Diephuis, M.; Armengol, I.; Doornbos, R.; Sanden, B. van der; Hulst, J. van; Zuijlen, R. van; Kohr, H.
Proof of Concept Demonstration and Evaluation – Use Case Electron Microscopy
This work presents the latest advancements in leveraging artificial intelligence (AI) and digital twin (DT) technologies to automate the operation of electron microscopes, with a particular focus on exploring the feasibility of automated electron microscope alignment. The alignment of electron microscopes is a laborious process, demanding significant time and expert knowledge.
- Year
- 2024
- Authors
- Antunes, D.G.T.; Armengol, I.; Bikker, J.W.; Baun, N.; Diephuis, M.; Doornbos, R.; Schmidt, L.; Hulst, J. van; Hajnorouzi, M.; Modrakowski, E.; Sanden, B. van der; Henning, T.
Architecture and technical approach for DT-supported AI-based training and system optimization
WP3 is concerned with the development of a technical approach and a reference architecture for DT-supported AI-based system optimisation. System optimisation can be performed by connecting AI to both the physical system and its DT. By allowing the AI to take control over the DT, a learning cycle based on reward and punishment can be constructed to validate its actions.

